Vascular smooth muscle cell activation by C-reactive protein

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Vascular smooth muscle cell activation by C-reactive protein.

OBJECTIVE C-reactive protein (CRP) is an important cardiovascular risk factor. Although the role of CRP has been implicated in atherogenesis, its direct effects on vascular cells are poorly defined. METHODS We investigated the responses to CRP in vascular smooth muscle cells (VSMC). RESULTS The present study shows that CRP induces parallel activation of the redox-responsive transcription fa...

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C-reactive protein (CRP) is considered to induce the inflammatory response during atherosclerosis. Toll-like receptor 4 (TLR4)-mediated inflammatory signaling has been shown to facilitate atherogenesis. It remains thoroughly unknown whether TLR4 mediates the proinflammatory effect of CRP. Thus, the study was designed to explore TLR4-related mechanism of proinflammatory effect of CRP in rat vasc...

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Vascular smooth muscle cell activation by glycated albumin (Amadori adducts).

Nonenzymatic glycation is increased in diabetes. The role of advanced glycation end products has been implicated in many of the complications of diabetes, whereas the effects of early-glycation Amadori-modified proteins on vascular cells alone are poorly defined. In the present study, we show that glycated serum albumin (GSA) induces a parallel activation of the redox-responsive transcription f...

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Reactive oxygen species induce apoptosis of vascular smooth muscle cell.

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2003

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(02)00855-6